What factors promote progression from initial use of drugs to drug abuse and dependence?
One recent study examined how volunteers respond to amphetamine in a recreational environment. Similar to studies with rats, this research shows that the same volunteers who demonstrate the greatest increase in spontaneous motor activity when first exposed to the test environment also show the greatest amphetamine-induced increase in motor activity. Thus, the extent to which experience-seeking behavior in a novel recreational environment predicts psychostimulant response and drug-taking is an important question for future study.
Source, National Institute on Drug Addiction, NIDA, USA.gov
By Robert Mathias & Neil Swan, NIDA NOTES